Cayne lies about many of the details that he gives Rick Henderson, such as stating that 47 stole cloning data from Ort-Meyer to sell to the highest bidder. It quickly becomes clear that Cayne's real intent is to discuss his views on human cloning and his obsession with capturing the genetically engineered super assassin. The reporter, Rick Henderson, arranged to interview Cayne in regards to a recent attack on the White House. The two discuss a number of contract kills over the past two years (2004-2005) and Agent 47's involvement in them. The majority of the game takes place as flashback sequences that occur through the meeting between a journalist and a former FBI Director, “Jack” Alexander Leland Cayne.
